Use of photobiomodulation therapy for the evolution of immunomodulatory markers and physiological parameters in patients with covid-19

The study aimed to evaluate the effectiveness of laser therapy for the evolution of immunomodulatory markers and physiological parameters in patients with COVID-19 with moderate to high risk of death. Twenty seriously diagnosed patients with COVID-19 were selected for the study, which were divided into two groups: control (who did not receive the treatment) and laser (who received the treatment), selected through non-blind randomization. The laser was administered in five areas: pulmonary area, face, tonsillar fossae, trachea, and bronchi. The treatment was monitored throughout its duration, six days. Laboratory tests were collected daily in both groups and several parameters were measured. We tested the difference between the days with paired tests and tested the correlation of the parameters with time using Pearson's correlation. In the laser group, patients showed a constant improvement in partial arterial oxygen pressure (PaO2) when compared to patients in the control group. Therefore, when thinking about intervening in the pathophysiology of the disease, one should take into account the use of techniques or drugs that can act both in restricting the most pernicious phase of the inflammatory cascade and in modulating all events related to the evolution of COVID- 19.