The role of selenium in the protection against oxidative stress in patients with chronic renal disease
International Journal of Development Research
The role of selenium in the protection against oxidative stress in patients with chronic renal disease
Received 11th April, 2020; Received in revised form 14th May, 2020; Accepted 09th June, 2020; Published online 30th July, 2020
Copyright © 2020, Islanne Leal Mendes, Camila Santos Marreiros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Studies have shown the participation of minerals, such as selenium, involved in the antioxidant defense of patients with chronic kidney disease. Therefore, the purpose of this review is to provide data on nutrient participation in the control of the antioxidant defense system in individual’s withchronic renal disease. A search of articles published in the PubMed and ScienceDirect database selected from March 2017 to February 2019 was performed using the keywords Selenium, Selenium supplementation, Oxidative stress, Antioxidant and Chronic Kidney Disease. Following the eligibility criteria, 39 articles were selected. The scientific evidence presented in this review shows the importance of selenium as an antioxidant for the reduction of oxidative stress in renal patients, thus, thesupplementation of this mineral can result in the reduction of oxidative stress, through your involvement in selenoprotein and GPx, inhibiting the production of reactive oxygen species; however, the efficacy of the intervention with selenium supplementation is still inconclusive.
