Resveratrol in topic preparation as a preventive to skin photoaging: A systematic review

Background: The increase in research in the cosmetic area on resveratrol, mainly due to its antioxidant action and the existence of few in vivo studies proving its effective action against topical skin photoaging, are the antecedents of this research. Aims: To evaluate, through systematic review, scientific evidence that proves the antioxidant activity of resveratrol in preparation for topical use as a preventive to photoaging. Methodology: The research was carried out in the Cochrane, Scielo, Science Direct, Pubmed, Web of Science, and Scopus databases, using in vitro and in vivo studies with topical resveratrol application. Data published from 1999 to March 2020 were considered. Results: Through the search strategies presented, 714 articles were found in the databases searched. Of these, 29 were duplicated, leaving 685 articles. After reading the title and summary of these articles by two reviewers, 30 articles partially met the inclusion criteria and were selected for a full reading. Of these, 9 met all criteria and were included for data extraction. Conclusion: Topical preparations added with RSV acted as a preventive to photoaging, and the primary prevention mechanism, in general, is linked to its antioxidant activity. It was also shown that this antioxidant action could be higher when RSV is applied in formulations associated with other antioxidants and in their synthesized analogous forms.