Rbm3 and cirp may play an important role as avasodilator. a preliminary study

It is now well accepted that e-NOs is one of target genes of HIF-1 and it plays an important role as a vasodilator or angiogenesis. We found in our series of immune his to chemical study that anti- RBM3 and CIRP antibodies were able to stain the nucleuses of neurons, myocardial cells and cells in the blood vessels existing in the newly infarction area of the brain and myocardium, although moderate or feeble reactivity with those antibodies were observed in sub-acute and/or chronic infarction area. The reactive manner of them were basically resemble to those by anti e-NOs antibody, and showed more intensive and clear compared with those by anti e-NOs antibody. It has been shown in our previous studies that expression of RBM3 and CIRP in the heart and/or brain occurred in response to cellular stressors, such as hypoxia and hypothermic conditions, where they may attenuate both apoptosis and necrosis. The results observed in this study additionally indicate that RBM3 and CIRP may also play an important role as a vasodilator mechanism in hypoxic-ischemic condition and show a priority role to detect the hypoxia status in the tissues obtained at forensic autopsies.