Preparation of statistical copolymers of trimethylene carbonate and lactide: candidate materials for medical applications
International Journal of Development Research
Preparation of statistical copolymers of trimethylene carbonate and lactide: candidate materials for medical applications
Received 20th January, 2021; Received in revised form 07th February, 2021; Accepted 18th March, 2021; Published online 28th April, 2021
Copyright © 2021, Alexandre Carneiro Silvino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copolymers of trimethylene carbonate (TMC) and L-lactide (LA) with distinct compositions were prepared in solution employing [Mg(OEt)2]2∙[Ti(OBu)4] as initiator. Our results showed that the reactions in solution are considerably slower compared with the same copolymerizations carried out in bulk, however the copolymer ratios observed by NMR tracks the feed ratio excellently when the reactions were performed in toluene at 90o C. The values of degree of randomness (R) calculated for the copolymers were always lower than 1, confirming the preference for L-lactide incorporation, with LA microblocks slightly larger than expected. The effect of the composition in the thermal properties of the copolymer was also investigated by DSC
