Osteomyelosclerosis: A Rare Presentation Of Myeloproliferative Neoplasm: A Rare Case Report And Review Of Literature
International Journal of Development Research
Osteomyelosclerosis: A Rare Presentation Of Myeloproliferative Neoplasm: A Rare Case Report And Review Of Literature
Received 08th April, 2018 Received in revised form 16th May, 2018 Accepted 08th June, 2018 Published online 30th July, 2018
Copyright © 2018, Vinisha Bansal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) characterised by neoplastic megakaryocytic proliferation and extensive marrow fibrosis. Rarely in later stages, the bone marrow is replaced by calcified connective tissue referred to as osteomyelosclerosis, but it is seldom seen at presentation. Leukemic transformation in PMF is frequently seen in later stages of primary myelofibrosis and is associated with a dismal prognosis. Here, we present a case of a 44-year-old female presenting with MPO negative acute leukemia as a primary presentation of PMF with histological finding of osteomyelosclerosis on trephine biopsy, which is a relatively rare presenting feature and a rare histological finding in PMF.
