Chronic kidney disease and healthy bone: a review

Background: Chronic Kidney Disease (CKD) is defined as an abnormality of the renal structure or function, present for more than three months, with implications for health as a whole (OKORIE et al., 2018), with increasing epidemiological importance, health burden public and social and economic implications. Patients with CKD are usually inserted in a systemic context of chronic and severe inflammatory disease, which involves several organs, resulting in a vicious circle oxidative stress, also compromising the osseointegration process. Objeticve: Describe the main bone diseases associated with CKD and their pathophysiological principles. Methods: Literary review based on articles from Pubmed, CAPES, Scielo and Google Academic platforms, in Portuguese, English and Spanish. Results: Description, based on referenced articles of the most prevalent bone diseases in CKD, their pathophysiology, diagnoses and treatment. Conclusion: Although very common and widely discussed, there are unanswered gaps in the link between CKD and bone disease secondary to this disease. It is expected that, with the advancement of research, biological markers and more enlightening tests, these gaps will be filled in order to prevent, attenuate evolution or lead to more appropriate and individualized therapeutic approaches, improving quality of life, survival and decreasing the cardiovascular risk in chronic renal patients.