Activity of hydroalcoholic extracts of commonly discarded seeds of theobroma grandflorum against the vector of arboviruses aedes aegypti

Arboviruses are still diseases considered a global threat to public health, being transmitted by the vector Aedes aegypti, belongs to the family Culicidae. They are hematophagous mosquitoes in which they adopt humans as amplification hosts to ensure the transmission of arboviruses. Aiming at an alternative proposal with the use of a plant source in vector control, the present study aims to evaluate the chemical composition and larvicidal activity of hydroalcoholic extracts of Seeds of Theobroma grandiflorum (Willd. ex Spreng). The extracts were prepared from maceration in extractor ethanol 70%PA solvents in hydromodulus 1:4/1:6/1:8 in 7 days with subsequent concentration in rotaevaporator. On the other, larvicidal activity achieved by the WHO method of Lethal Concentration 50% against Aedes aegypti larvae with statistics by Probit method. Toxicity to non-target organisms was verified by artemia saline test. Larvicidal activity with CL50 was evidenced ranging from 35.018 to 369.191 mg L-1 with a 95% confidence interval. It is noted that the extract T. grandiflorum exhibits high larvicidal potential and has no toxicity to target organisms. It is observed that the extract of T. grandiflorum is shown to be a promising and sustainable strategy in the fight and control of Aedes aegypti larvae.