Evaluation of plasma protein levels klotho and stress urinary incontinence in elderly women and the impact on quality of life

Background: Klotho is a protein that acts as a well-known anti-aging hormone, which serves as a suppressant of aging through a variety of mechanisms. The aging of skeletal muscle is concomitant with a decrease in the function of muscle stem cells, resulting in impaired regeneration. Stress urinary incontinence in women is still considered a challenge for medicine, impacting the quality of life of its carriers and its basic cause is tissue damage to muscle groups responsible for the support and functionality of the lower urinary tract. Objective: to study the potential functional role of Klotho protein in the tissue repair function of elderly patients with stress urinary incontinence was investigated, comparing its serum dosage to that of patients without the same pathology. In addition, in order to assess the impact caused by stress urinary incontinence in the lives of these women, a validated quality of life questionnaire was applied. Results: in assessing the quality of life measured by questionnaire of patients with urinary incontinence, it was observed, in relation to the severity of symptoms, that 62.5% of the patients reported that stress urinary incontinence interfered a lot in their lives. Discussion and conclusion: It was observed that patients with stress urinary incontinence had serum levels of klotho protein on average, higher compared to the group without urinary incontinence, translating possible biases and the need for long-term longitudinal studies.