Use of topical clindamycin in the treatment of root surface in delayed teeth replantation – study in rats
International Journal of Development Research
Use of topical clindamycin in the treatment of root surface in delayed teeth replantation – study in rats
Received 11th March, 2021; Received in revised form 26th April, 2021; Accepted 20th May, 2021; Published online 30th June, 2021
Copyright © 2021, Wâneza Dias Borges Hirsch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This study aims to evaluate dentoalveolar repair after topical use of clindamycin as root surface treatment of replanted teeth. Fourteen Wistar rats had the right maxillary incisor extracted and stored dry. The periodontal ligament was removed chemically by immersion in 1% sodium hypochlorite. Specimens were distributed into an experimental group (immersion in clindamycin solution for 5 minutes) and a control group (no topical antibiotic treatment) and then replanted. After 90 days, specimens were examined histologically, and variables were analyzed using the Fisher exact test (p<0,05).Showed no inflammatory infiltrate or up to 10% of the field in both groups. In the control group, periodontal ligament fibers were reinserted in a disorganized way, and there were areas of replacement and inflammatory resorption and ankylosis. In the experimental, there was no reinsertion of the periodontal ligament fibers, and there were few areas of inflammatory resorption, but extensive areas of replacement resorption and ankylosis. Chemical removal of periodontal ligament together with topical use of clindamycin resulted in few and small areas of inflammatory resorption, but marked ankylosis along the root surface.
