Dedifferentiated liposarcoma with low grade differentiation - a case report

Introduction: Dedifferentiated liposarcoma (DDLS) is a rare sarcoma accounting for only 2% of all soft tissue sarcomas.It is the most common liposarcoma of the retroperitoneum. It is defined as the morphological progression of a well-differentiated liposarcoma to a nonadipocytic sarcoma. Case Presentation: A 61 years old male presented to the outpatient department with symptoms of abdominal pain associated with distension for a duration of 2 months. A CT abdomen performed outside hospital showed a retroperitoneal mass for which he underwent a retroperitoneal tumor excision. Histopathological report of the excised tumor was given as pT2b Nx cM0- Grade 2, Dedifferentiated liposarcoma with low grade differentiation towards smooth muscle. Discussion: The non adipocytic component of DDLS is 90% of times a high grade sarcoma. This paper presents a case of dedifferentiated liposarcoma of the retroperitoneum showing a low grade differentiation towards smooth muscle. This case has been chosen here for discussion here to the infrequent occurrence of low grade differentiation.