Análise de interações medicamentosas potenciais de prescrições médicas em uma drogaria da região noroeste paulista

The association between medications is a widely used therapeutic tool; however, this practice increases the rate of drug interactions (DI). Objective: This study examines potential drug interactions present in medical prescriptions of a private drugstore. Methods: A total of 1730 medical prescriptions were analyzed. The survey to assess potential DI was carried in the MICROMEDEX® database. Drug interactions were classified into minor, moderate, severe and contraindicated; into pharmacodynamics or pharmacokinetics. Results: The prescriptions comprised 2370 active ingredients, the main ones being antimicrobial (46.9%) and psychotropic (34.6%). Of the individuals that composed the sample, 63.6% were female. In terms of age, 44.8% were elderly, 41.3% adults, 8.4% children and 5.5% adolescents. Prescriptions that comprised more than one medication totaled 26.7% of the analyzed sample, and 20.1% were at risk of possible DI, were 3.2% at a low risk, 3.2% moderate risk, 92.5% severe risk and 1.1% were contraindicated, 14% pharmacodynamics and 86% pharmacokinetics. Conclusions: The use of antimicrobials, analgesics and corticosteroids, associated with NSAID, has proved to be very common, although they can promote severe DI, with significant clinical repercussions. Therefore, knowledge of the topic by drug-prescribing health professionals is important to help prevent possible harmful effects on the patient's health.