Kaposi sarcoma in people living with Hiv/Aids: clinical and histopathological aspects of cutaneous lesions of patients attended at a reference University Hospital in Amazon region

Kaposi's sarcoma (KS) corresponds to a systemic malignant and multifocal disease with a distinct clinical course, most commonly associated with Human immunodeficiency (HIV). Case series study to describe the clinical forms and histopathological changes of cutaneous lesions in patients with Kaposi's sarcoma and HIV coinfection at reference university hospital in Amazon region, from 2014-2017. From 20 individuals, 95% were male, mostly composed of young adults (35.1 years). Time of serological diagnosis: 11.67months and a skin lesion time: 11.47months. Cutaneous lesions were found in 3 forms: macule, infiltrated plaque and nodule located in different corporal segments. Immunological and virologic: 40% of individuals with <200 T-CD4 +cells/mm³ and 25% viral load above 10,000copies/ml. In all these forms: epidermis was found without alterations; with diffuse neoplastic distribution in papillary and reticular dermis, spindle cells, hemosiderin deposit, promontory sign, hyaline inclusions, extravasated red blood cells, anomalous capillaries and absence of desmoplasia. Infiltrate form red blood cells in subcutaneous. Nodular form: atypical endothelial cells and mitotic figures. Serological profile: 100% of HIV+ individuals were confirmed and the presence of KS confirms the prevalence of AIDS.