Study of microcrystalline cellulose as a substitute of magnesium stearate towards functionality of lubricant in aspirin formulation
International Journal of Development Research
Study of microcrystalline cellulose as a substitute of magnesium stearate towards functionality of lubricant in aspirin formulation
Received 29th July, 2017; Received in revised form 23rd August, 2017; Accepted 27th September, 2017; Published online 10th October, 2017
Copyright ©2017, Jilika Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it decreases hardness of tablet in some formulations. Microcrystalline cellulose is very good excipient, it has excellent binding property. In solid dosage forms, it works as a good lubricant, disintegrant, binder and filler. Concentration of lubricants in formulation should be balanced in terms of the adverse effects of used lubricant. In this study we have manufactured aspirin tablets by direct compression with different concentration (0.05% to 2.00%) of magnesium stearate and microcrystalline cellulose and then evaluated pre compression and post compression study. In pre compression study, we have evaluated bulk density, tapped density, angle of repose of aspirin tablet blend and in the post compression study, we have evaluated weight uniformity, hardness, percentage friability, disintegration time and dissolution profile of aspirin tablet.
