Maternal deprivation by early weaning causesthe nociceptinto alter the palatability and cookie consumption
International Journal of Development Research
Maternal deprivation by early weaning causesthe nociceptinto alter the palatability and cookie consumption
Received 06th February, 2021; Received in revised form 19th March, 2021; Accepted 22nd April, 2021; Published online 22th May, 2021
Copyright © 2021, Mayara Matias de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The deprivation of maternal care during the initial development period, as well as interruption of early breastfeeding, promotes changes in eating behavior, however, the underlying neuromodulatory mechanisms have not been fully understood. Studies demonstrate theimportance of the nociceptin receptor (NOP) in modulating the immediate hedonic impact and the hyperphagic effect associated with nociceptin/orphanin FQ (N/OFQ or nociceptin) overexpression. In the current study, experiments have beenperformedto understand the impact of early weaningon the control of hedonic eating behavior and the NOP system's modulatory performance on the resulting phenotype of this injury. Early weaning promotespreference and increasespalatable food consumption, compared to the control group. The NOP receptor antagonist (SB 612111) isable to normalize the palatable food consumption in animals of theearlyweanedgroup, in addition to reducing this consumption in the control group. These results are concordant with the hypothesis that changein hedonic eating behavior, resulting from early weaning are influenced by the NOP system,which, in turn, enhances its potential as a therapeutic target for obesity.
