Immunological response and zika mutations as a mechanism of microcephaly: systematic review and meta-analysis
International Journal of Development Research
Immunological response and zika mutations as a mechanism of microcephaly: systematic review and meta-analysis
Received 06th January, 2021; Received in revised form 20th February, 2021; Accepted 26th March, 2021; Published online 28th April, 2021
Copyright © 2021, Willma José de Santana et al, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Several circumstances may involve the development of microcephaly in the context of Zika infection. Mutations and the immune response caused by the virus may be part of the theoretical direction in the context. The aim of this study was to analyze the relationship between immune response or zika mutation and the development of microcephaly. A systematic review was conducted with meta-analysis on immunology and zika mutations in the development of microcephaly. A literature search was conducted on PubMed e Scopus online databases, with a search period for the past 5 years. The results of the analysis showed an effect on the immune response of 0.76 and for mutations of the zika virus of 0.60, which represent, in both cases, an average effect with probability of superiority above 63%.These results represent the clinical significance that the immune response and mutations related to zika virus represent in the development of microcephaly. Mutations and the immune response mediated by interferons significantly influence the development of microcephaly.
