High-Functional Self-Lubricating Excipient Performance Comparison with Physical Blend
International Journal of Development Research
High-Functional Self-Lubricating Excipient Performance Comparison with Physical Blend
Received 20th October, 2023; Received in revised form 06th November, 2023; Accepted 11th December, 2023; Published online 30th January, 2024
Copyright©2024, Rauf Pathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A microcrystalline cellulose-based excipient having improved lubrication sensitivity and flowability, whether utilized in oral solid dosage forms, in direct compression, wet and dry granulation tablet manufacturing, or hard capsule filling and dry syrup formulation. Self-lubricating excipient BARETab Lub is an agglomerate of microcrystalline cellulose particles and from 0.1 to 0.8 % lubricant Magnesium stearate, by weight of the Microcrystalline cellulose, wherein the microcrystalline cellulose and magnesium stearate particles are in intimate association with on each other. The lubricant magnesium stearate is used in pharma and Nutra as a novel lubricant to make solid oral dosage forms. Self-lubricating excipients don’t affect tablet properties like hardness, disintegration time, and dissolution of the tablet, BARETab Lub improves Particle BET surface area, and Physical properties. In this study, we will blend the self-lubricating excipient physical properties, BET surface area, FTIR, SEM, and the impact of blending time on the Self-lubricating excipient and physical mix of MCC and Magnesium stearate.