Graft versus host disease: oral clinical aspects, diagnosis, and treatment in dental practice

Introduction: Hematopoietic Stem Cell Transplantation (HSCT) is a therapeutic modality for hematological diseases, and the use of which can trigger secondary problems, and one of them is the Graft Versus Host Disease (GVHD). Objective: To report the pathogenesis, diagnostic, treatment and clinical oral manifestations of GVHD. Methodology: This is a narrative literature review, with data collection in the Pubmed, was used from December 2019 to February 2020. The crossing was made through the descriptors Decs / Mesh “graft-versus-host disease”, “oral graftversus-host disease”, “allogeneic bone marrow transplant” and “oral manifestations”. A total of 32 articles were included to this review. Results: The determination of the diagnosis through the clinical manifestations of oral GVHD is well established in the literature, however there is a lack of suficient content to support the pathogenesis and treatment options. Further studies are necessary to improve understanding, collaborating for the elaboration of more effective therapeutic strategies. Final Considerations: It is emphasized the importance of a systemic analysis of the patient for the correct diagnosis, because the treatment becomes more satisfactory and effective.