G-protein Coupled Receptors (GPCR) as Drug Targets
International Journal of Development Research
G-protein Coupled Receptors (GPCR) as Drug Targets
Received 17th March, 2019; Received in revised form 05th April, 2019; Accepted 10th May, 2019; Published online 30th June, 2019.
Copyright © 2019, Abdulrahman Alshamrani Alshamrani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Protein Coupled Receptors (GPCRs) are proteins extensively expressed, and they wind the cell membrane seven times (Salon, Lodowski and Palczewski, 2011 p. 902). GPCRs also respond to a wide range of stimuli which include lipids, peptides, and cations (Ghanemi, 2015 p. 115). GPCRs are seen as the target for non-oncology drugs.Therefore, precisely, GPCRs control the majority of pathways for signal changes, which are pertinent in cancer cells (Lappano and Maggiolini, 2011 p. 47). GPCRs are frequently hijacked by malignant cells given the fact that they control and crosstalk with critical pathways (Zhang, Scoumanne and Chen, 2010 p. 112).
