Formulation, Evaluations and Applications of Solid Lipid Nanoparticle

The liquid crystalline state has both the properties of liquid and solid. The liquid state is found to associate with flow property whereas the solid state has structural properties of crystallinity in aspects of orientation and position. Liquid crystalline phases represent intermediate states and are also called asmesophases. The studies were done with different formulations to ensureits controlled drugrelease and bioavailability research has progressively highlighted on clues from conventional use of herbal medicines to introduce new anticancer drugs. Aloe-emodin (AE) is a herbal drug with promising anticancer activity. Nevertheless, its clinical utility is handicapped by its low solubility. PEGylated LCNPs could serve as a promising nanocarrier for efficient delivery of AE to cancerous cells. In this review attention is focused to give the brief regarding formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nano emulsions, several techniques are to be used for preparation of nanoemulsions like microfluidization, high pressure homogenization, low energy emulsification and solvent evaporation method and parameter that are to be used for its characterization like droplet size analysis ,viscosity determination, drug content, refractive index, pH, zeta potential, Transmission electron microscopy, thermal stability, release and in vitro skin permeation study. These are applicable in drug targeting.