Formulation and in vitro evaluation of sustained release matrix tablets of candesartan cilexetil

International Journal of Development Research

Volume: 
13
Article ID: 
26426
6 pages
Research Article

Formulation and in vitro evaluation of sustained release matrix tablets of candesartan cilexetil

CH. Lavanya Sri, P.S.S. Prasanna Kumar, Srinivas Nandyala and T. Anjali

Abstract: 

The aim of the present study was to develop sustained release formulation of Candesartan cilexetilto maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 100 M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F9) showed better and desired drug release pattern i.e., 99.9% in 12 hours. It contains the HPMC-K 100 M 1:1as sustained release material. It followed Zero order release kinetics mechanism.

DOI: 
https://doi.org/10.37118/ijdr.26426.02.2023
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