Formulation and in vitro evaluation of sustained release matrix tablets of candesartan cilexetil
International Journal of Development Research
Formulation and in vitro evaluation of sustained release matrix tablets of candesartan cilexetil
Received 11th January, 2023; Received in revised form 17th January, 2023; Accepted 20th February, 2023; Published online 28th February, 2023
Copyright©2023, Lavanya Sri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The aim of the present study was to develop sustained release formulation of Candesartan cilexetilto maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 100 M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F9) showed better and desired drug release pattern i.e., 99.9% in 12 hours. It contains the HPMC-K 100 M 1:1as sustained release material. It followed Zero order release kinetics mechanism.
