Diabetes mellitus type 1 and hypovitaminosis d: current clinical associations
International Journal of Development Research
Diabetes mellitus type 1 and hypovitaminosis d: current clinical associations
Received 05th October, 2017; Received in revised form 26th November, 2017; Accepted 20th December, 2017; Published online 31st January, 2018
Copyright©2018, Omar Pereira de Almeida Neto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: to analyze scientific publications about the relation between hypovitaminosis D and Diabetes Mellitustype 1 (DM1). Method: Integrative literature review, using the descriptors "Type 1 diabetes mellitus/diabetes mellitus tipo 1" and "vitamin D deficiency/deficiência de vitamina D" connected by the Boolean operator AND in the Pubmed, Lilacs and SciElo databases. Papers published between 2010-2017 was included, available in their entirety in Portuguese, Spanish and English, and the ones that answer this study main question. Results: From the 237 papers found, just 6 answered this study main question. The hypovitaminosis D is related to DM1 by the following evidences: low sunlight exposure; modulation of the inflammatory response; increase and control of pancreatic secretion; control of autoantibodies in pancreatic islets; expression of C reactive protein in inflammatory processes. Conclusion: The literature is scarce of publications that establish a relation between hypovitaminosis D and DM1. Experimental and prospective investigations need to be done to solidify the studied theme.
