Development study of magistral cosmetic formulations containing 5% caffeine

This article refers to an approach to the development of semi-solid formulations containing 5% caffeine for the cosmetic treatment of cellulite. In a bench analysis proposal, five formulations were developed, three emulsions and two base gels that demonstrated when incorporating caffeine, the gels showed turbidity and to correct this problem it was necessary to add cosolvent. The samples were tested in the centrifuge test in a preliminary stability study, evaluating organoleptic characteristics, pH, microbiological control and viscosity determination at time zero and at the end of four weeks, using a commercially available sample as a control group. The parameters pH and average weight were statistically analyzed by the Tukey test at 5% significance. Considering the results obtained, it was concluded that the proposed emulsions and gels proved to be able to incorporate 5% caffeine under the conditions of this study. These formulations demonstrated the maintenance of physicochemical characteristics, with quality similar to the standard emulsion. This is a preliminary stability study, and should be complemented with other stability studies under conditions determined by current legislation, in order to prove the effectiveness of the developed formulations.