Coconut oil action on the hepatic function of rats wistar submitted to the diet hypercaloric

Objective: To evaluate the effect of coconut oil on animals submitted to the hypercaloric diet considering its possible hepatoprotective effect. Method: Seven animals Were included in each of the experimental groups, totaling 28 animals: G1 (hypercaloric diet); G2 (+ hypercaloric coconut oil); G3 (control: commercial ration) and G4 (commercial diet + coconut oil) and sacrificed after 54 days of diet. Blood collection was Performed to Obtain the serum levels of transaminases, and tissue for histological analysis of the liver.Results: The hypercaloric diet with or without coconut oil did not please weight gain. However, the group fed with hypercaloric and coconut oil ration (9:30 22:49 ± grams) had Significantly higher than the visceral fat G3 (14.07 ± 4.11 grams) and G4 (13:01 3:53 ± grams). There was significant difference in the serum AST values between groups, but the greater G2 presented expression (223.00 ± 106.18U / L). Only animals fed commercial feed supplemented with coconut oil (72.00 ± 19:00 U / L) presented significant differences in relation to ALT levels When Compared to the hypercaloric diet groups (43.43 ± 19.12 U / L) and high calorie diet with coconut oil (46.43 ± 15:02 U / L). The liver sections of the animals submitted to the diet hypercaloric presented histopathological differences with each other by optical microscopy When Analyzed. Conclusion: Our results suggest of coconut oil did not present a hepatoprotective effect, however, other studies need to be developed to better elucidate this relationship. Only animals fed commercial feed supplemented with coconut oil (72.00 ± 19:00 U / L) presented significant differences in relation to ALT levels When Compared to the hypercaloric diet groups (43.43 ± 19.12 U / L) and high calorie diet with coconut oil (46.43 ± 15:02 U / L). The liver sections of the animals submitted to the diet hypercaloric presented histopathological differences with each other by optical microscopy When Analyzed. Conclusion: Our results suggest que coconut oil did not present a hepatoprotective effect, however, other studies need to be developed to better elucidate this relationship. Only animals fed commercial feed supplemented with coconut oil (72.00 ± 19:00 U / L) presented significant differences in relation to ALT levels When Compared to the hypercaloric diet groups (43.43 ± 19.12 U / L) and high calorie diet with coconut oil (46.43 ± 15:02 U / L). The liver sections of the animals submitted to the diet hypercaloric presented histopathological differences with each other by optical microscopy When Analyzed. Conclusion: Our results suggest que coconut oil did not present a hepatoprotective effect, however, other studies need to be developed to better elucidate this relationship. The liver sections of the animals submitted to the diet hypercaloric presented histopathological differences with each other by optical microscopy When Analyzed. Conclusion: Our results suggest que coconut oil did not present a hepatoprotective effect, however, other studies need to be developed to better elucidate this relationship. The liver sections of the animals submitted to the diet hypercaloric presented histopathological differences with each other by optical microscopy When Analyzed. Conclusion: Our results suggest que coconut oil did not present a hepatoprotective effect, however, other studies need to be developed to better elucidate this relationship.