Chemiopreventive effect of probiotics on experimental carcinogenesis induced by 1,2-dimethyhthrazine in rats
International Journal of Development Research
Chemiopreventive effect of probiotics on experimental carcinogenesis induced by 1,2-dimethyhthrazine in rats
Received 20th March, 2021; Received in revised form 18th April, 2021; Accepted 17th May, 2021; Published online 26th June, 2021
Copyright © 2021, Marceli Pitt Coser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The disorder between beneficial microorganisms and pathogens generates dysbiosis. Probiotics balance the environment and demonstrate efficacy in the prevention and treatment of neoplasms. This study aimed to evaluate the effect of the probiotics Lactobacillus helveticus and Bifidobacterium bifidum, isolated or combined, on the carcinogenic effect induced by 1,2-dimethylhydrazine in rats. Six different experimental groups were used, containing six animals each, and the treatment occurred for six weeks. Body mass gain, pro-carcinogenic enzyme activity, quantification of aberrant crypts, measurement of intestinal macroscopic changes, and colorectal histological evaluation were evaluated. Through the analysis of the results, it can be observed that the probiotics were shown to be effective in decreasing the colorectal toxicity induced by 1,2-dimethylhydrazine, and promising chemopreventive on intestinal lesions.
