Chemiopreventive effect of probiotics on experimental carcinogenesis induced by 1,2-dimethyhthrazine in rats

International Journal of Development Research

Volume: 
11
Article ID: 
21975
7 pages
Research Article

Chemiopreventive effect of probiotics on experimental carcinogenesis induced by 1,2-dimethyhthrazine in rats

Marceli Pitt Coser, Conrado Gamba de Oliveira, Jane Mary Lafayette Neves Gelinski and Claudriana Locatelli

Abstract: 

The disorder between beneficial microorganisms and pathogens generates dysbiosis. Probiotics balance the environment and demonstrate efficacy in the prevention and treatment of neoplasms. This study aimed to evaluate the effect of the probiotics Lactobacillus helveticus and Bifidobacterium bifidum, isolated or combined, on the carcinogenic effect induced by 1,2-dimethylhydrazine in rats. Six different experimental groups were used, containing six animals each, and the treatment occurred for six weeks. Body mass gain, pro-carcinogenic enzyme activity, quantification of aberrant crypts, measurement of intestinal macroscopic changes, and colorectal histological evaluation were evaluated. Through the analysis of the results, it can be observed that the probiotics were shown to be effective in decreasing the colorectal toxicity induced by 1,2-dimethylhydrazine, and promising chemopreventive on intestinal lesions.

DOI: 
https://doi.org/10.37118/ijdr.21975.06.2021
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