Caffeine effect on non-motor symptoms in an animal model of parkinson disease

It has been shown that A2A receptor antagonist drugs have beneficial effects on neuroprotection and control of the motor symptoms of Parkinson's disease; however, their effects on non-motor symptoms are virtually unknown. This study aimed to evaluate the effect of caffeine on non-motor symptoms in an animal model of Parkinson's Disease. The experiment was composed of two groups, the saline and the MPTP group, each composed of three subgroups. The animals received saline or MPTP for five consecutive days and after one day were treated with saline, caffeine 10 mg / kg or 20 mg / kg; after the tests of Elevated plus maze, Open field and Tail suspension test as well as the Discrimination Olfactory test were performed and recorded. The data and statistical analysis were performed by the Kruskal-Wallis test with Dunn post-test, with a significance level of p <0.05. It was observed that there was a small significant difference only in the CA and LCE tests, by which one cannot affirm any of the hypotheses raised, since the differences occurred among the random groups. Therefore it was not possible to verify the efficacy of caffeine on these symptoms.