Brocq-lyell syndrome induced by phenytoin. Clinical case

Stevens Johnson Syndrome (SJS) has been defined as a vesiculobullous multiforme erythema of the skin and other organs. It is considered to be the initial stage of a skin reaction which most severe form of presentation is Toxic Epidermal Necrolysis (TEN), characterized by intense pain and loss of the epithelial surface (greater than 30% of the body surface), compromising the vital functions of the organism, that produced electrolyte imbalance, kidney and ocular involvement, with high catabolism and potential risk of sepsis. Etiologically it is related to the use of drugs in 80% of cases. The treatment includes several immunomodulators, among which are systemic corticosteroids, cyclosporine, intravenous immunoglobulin, cyclophosphamide, plasmapheresis and inhibitors of tumor necrosis factor alpha. We reported a case of a 27-year-old woman with anticonvulsant treatment with phenytoin, who developed a NET which she survived due to the multidisciplinary approach in the hospital unit.