Blood pressure changes after supplementation of vitamin d in patients with chronic kidney disease: systematic review and meta-analysis
International Journal of Development Research
Blood pressure changes after supplementation of vitamin d in patients with chronic kidney disease: systematic review and meta-analysis
Received 28th December, 2020; Received in revised form 20th January, 2021; Accepted 16th February, 2021; Published online 15th March, 2021
Copyright © 2021, Otávio Luiz de Queiroz, Pedro Rafael Rocha Stermer, Matheus Silva Costa, Marianne Lucena da Silva, JosevanCerqueira Leal and Katiane da Costa Cunha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: To analyze the effects of vitamin D supplementation on blood pressure (BP) in patients with Chronic Kidney Disease (CKD). Method: For this systematic review, searches were performed in the databases PUBMED, COCHRANE LIBRARY, BVS, Embase and Web of Science for clinical trials about vitamin D supplementation in populations with CKD. The analysis of the articles had as selection criteria the outcome of searching for changes in blood pressure. Qualitative assessment for risk of bias in the studies included. Results: In the primary search in the databases, 204 articles were found. After screening and qualitative analysis, 8 works remained for final compilation, with a total population of 474 participants, of which 254 belong to the intervention group and 220 to the control group. Discussion: Vitamin D supplementation in patients with CKD shows no significant changes in blood pressure. Conclusion: No correlation was found between vitamin D supplementation and BP alteration in patients with CKD, however, the literature was sparse on the subject, so further research is needed to better understand the theme.
