Advancements in local drug delivery systems for periodontal disease Management: Current trends and Future Perspectives

Periodontal disease is a prevalent inflammatory condition that affects the supporting structures of teeth, leading to progressive tissue destruction and potential tooth loss. Traditional treatment methods such as scaling and root planing (SRP) and systemic antibiotic therapy have limitations, including inadequate drug penetration and antibiotic resistance. Local drug delivery (LDD) systems have emerged as an effective adjunct to conventional therapy by providing targeted and sustained drug release within periodontal pockets. Advances in nanotechnology, biomaterials, hydrogels, and 3D printing have significantly improved the efficacy and longevity of LDD systems. This review explores the evolution of LDD systems, their current applications, and emerging technologies that hold promise for future periodontal disease management.