8-Hydroxydeoxyguanosine in transitional bladder carcinoma

Objectives: As oxidative stress is known to be associated with the development of cancer, we investigated whether the tissue expression of 8-hydroxydeoxyguanosine (8-OHdG) which is a marker of DNA damage were increased in patients with transitional bladder carcinoma (TBC).
Design and Methods: Fifty patients with transitional bladder carcinoma (TBC) and 18 age-matched cancer –free patients were involved in this study. 8-hydroxydeoxyguanosine (8-OHdG) in tissue were examined by immunohistochemistry (IHC).
Results: Expression of 8-OHdG in transitional bladder carcinoma (TBC) tissues were higher than in control tissue. Significant differences were shown in 8-OHdG levels in the cancerous and cancer-free tissues between high grade and low grade TBC patients (P< 0.05)
Conclusions: 8-OHdG reflects oxidative stress in transitional bladder carcinoma tissue together with staging of cancer. Because of many factors that could influence the oxidative modifi¬cation of DNA bases, its role as a diagnostic and/or prognostic factor in transitional bladder carcinoma seems to be limited.