Effects of valeriana officinalis and passiflora sp on the behavior of wistar rats
International Journal of Development Research
Effects of valeriana officinalis and passiflora sp on the behavior of wistar rats
Received 14th June, 2017; Received in revised form 22nd July, 2017; Accepted 29th August, 2017; Published online 30th September, 2017
Copyright ©2017, Giselli Rizzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Anxiety affects millions of adults worldwide. Valeriana officinalis (VO) contains several active compounds that may work as anxiolytic as well as Passiflora sp (PA). Due to this reason, the aim of this study is to evaluate the acute and chronic effects of Valeriana officinalis and Passiflora sp in the behavioral test of Wistar rats. Wistar rats were divided into seven groups (n= 5): G1: a control group that received saline solution; G2, G3, and G4 were treated respectively with 11, 22 and 44mg/kg of VO extract and G5, G6 and G7 with PA in the same doses used with VO. Our results for the behavioral test showed that the use of VO and PA significantly modify the behavior of the rats. We verified that the acute treatment with doses of 22mg/kg for VO and 11 and 22mg/kg for PA resulted in a suggestive anxiolytic effect. For the chronic uses, doses of 44mg/kg (VO) and 22mg/kg (PA) resulted in a suggestive anxiolytic effect. Our results show that both VO and PA may exhibit anxiolytic effects in Wistar rats. In acute use of the plants, we may observe stronger effects of VO when comparing with PA. The opposite was seen in the chronic use of the plants.
