Alzheimer's alters ampk signaling pathway and biomarkers of subclinical inflammation in leukocytos stimulated with resveratrol
International Journal of Development Research
Alzheimer's alters ampk signaling pathway and biomarkers of subclinical inflammation in leukocytos stimulated with resveratrol
Received 17th August, 2020; Received in revised form 28th September, 2020; Accepted 04th October, 2020; Published online 30th November, 2020
Copyright © 2020, Luciana C. Cardoso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Alzheimer's disease (AD) is considered the most prevalent form of dementia in the elderly and represents the fifth leading cause of death in this population. In addition, free radicals seem to play a fundamental role in brain aging, since several studies have found an association between cytotoxicity promoted by the accumulation of βA and oxidative stress. In this context, Resveratrol (RSV) is a polyphenol that has antioxidant and anti-inflammatory activity. However, its mechanism of action in elderly AD is still unclear. Therefore, the aim of this study was to analyze the possible modulating and/or neuroprotective effect of resveratrol from human leukocytes isolated from patients without and with AD. Our results showed that RSV has both antioxidant and anti-inflammatory activity. Among its possible mechanism of action, there is a correlation between the AMPk cell signaling pathway. However, it was possible to observe that its action occurs more accentuated in elderly people without AD, having shown a greater neuroprotective effect.
