GC–MS analysis for compound identification in leaf extract of acanthus ilicifolius and evaluation of its in vitro anticancer effect against mcf-7 cell lines
International Journal of Development Research
GC–MS analysis for compound identification in leaf extract of acanthus ilicifolius and evaluation of its in vitro anticancer effect against mcf-7 cell lines
Received 08th September, 2019; Received in revised form 20th October, 2019; Accepted 26th November, 2019; Published online 31th December, 2019
Copyright © 2019, Vani, M. and Dr. T. Manikandan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The current study focused on GC-MS analysis for identification of bioactive compounds in leaf extract of mangrove plant, Acanthus ilicifolius leaf extract was tested for cytotoxicity against MCF-7 cell lines. The spectral properties (GC-MS) of each separated compound were determined and found the different compounds namely aziridine, alcohols, phenolic and fatty acid compounds. GC-MS analysis proved that the leaf extract of Acanthus ilicifolius contain a high content of ethanol compounds. The ethanol extract showed potent cytotoxicity against Human breast adenocarcinoma (MCF-7) cell lines, the viability of cancerous cells is reduced to 52.37% for MCF-7 cells. The high anticancer activity was found against Michigan Cancer Foundation (MCF-7) cell lines.
