Therapeutic diversification of azoles and their derivatives

About 30-40 years ago, relatively few agents of azoles were available for limited health problems. But in modern era, many classes of azoles have been introduced in market. Many azole compounds have been commercially developed and successfully proved beneficial in many human ailments including cancer. However, despite their widespread use, these agents became subject to a number of clinically important limitations related to their suboptimal spectrum of activity, the induction of hazardous drug-drug interactions, the development of resistance, their less than optimal pharmacokinetic profile and toxicity. In order to overcome these limitations, several analogues have been manufactured which have greater potency and possess increased activity against resistant and emerging pathogens. On the basis of authors’ researches, literatures have been discussed in a comprehensive review to understand the latest developments in azole derivatives therapeutics.