Lipidmediators pro-inflammationresolution in periodontal disease: review of literature

Periodontitis is classified as an inflammatory disease of the tissues of dental support caused by the deregulated production of inflammatory mediators against bacterial plaque, capable of destroying the periodontal ligament and alveolar bone, and can be of three types: chronic, aggressive and with manifestation of systemic diseases. The inflammatory process is the body's first defense response to disease facilities. However, exacerbation of the condition with excessive demand for inflammatory mediators may lead to the destruction of host tissue and produce irreversible pathologies. Within the non-prolonged inflammation there are biological and biochemical processes capable of removing the harmful stimulus, inducing the tissue repair through chemical mediators and lipid mediators, which are responsible for the end of the inflammation. After initiation of the inflammatory cascade, the following processes involving exacerbation or resolution of inflammation are controlled by inflammatory chemical mediators derived from cell production such as cytokines, and by lipid mediators from arachidonic acid, such as lipoxins, resolvins, maresinas.