Dual effect of 15-hydroxyprostaglandin dehydrogenase on reproduction and immunity in berkshire pigs

International Journal of Development Research

Volume:

Article ID:

9099

3 pages

Research Article

Jeongim Ha, Jung Hye Hwang, Seulgi Kwon, Da Hye Park, Tae Wan Kim, Deok Gyeong Kang, Go Eun Yu, Il-Suk Kim, Hwa Chun Park, Sang Mi An, and Chul Wook Kim

Received 24^th March, 2017; Received in revised form 29^th April, 2017; Accepted 15^th May, 2017; Published online 30^th June, 2017

Copyright© 2017, Jeongim Ha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract:

We investigated the differentially-expressed genes according to litter size in Berkshire pigs using RNA-Seq technology. Pigs were divided into two groups: the larger litter size group (LLG) and the smaller litter size group (SLG). The 15-hydroxyprostaglandin dehydrogenase (15-HPGD) gene was up-regulated in the LLG compared to the SLG. Reverse-transcription polymerase chain reaction (RT-PCR) confirmed the 2-fold increase in 15-HPGD in the LLG compared to the SLG. Since 15-HPGD prevents lip polysaccharide-induced inflammation, we hypothesize that 15-HPGD may play a dual role in reproduction and immunity. We propose that the 15-HPGD gene represents a molecular target for improving economically important traits in pigs, such as reproduction and resistance against diseases.

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