Comparative performance evaluation & systematic screening of 2-methf as green solvent for cost effective, improved industrial production of tramadol hydrochloride
International Journal of Development Research
Comparative performance evaluation & systematic screening of 2-methf as green solvent for cost effective, improved industrial production of tramadol hydrochloride
Received 22nd July, 2017; Received in revised form 23rd August, 2017; Accepted 27th September, 2017; Published online 10th October, 2017
Copyright ©2017, Sachin Sonavane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tramadol is a drug with analgesic properties. 2-Methyltetrahydrofuran (2-MeTHF) is employed as single solvent system for synthesis of Tramadol base, which involves Mannich base preparation followed by Grignard reaction. The solvent effect on the Grignard reaction as well as subsequent stages either for isolation or extraction has been systematically evaluated based on reaction efficiency, ease of subsequent work-up, safety and greenness. 2-Methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources, had superior impact on overall process. It is therefore a recommended alternative solvent to Et2O and THF for the preparation of Grignard reagents in Tramadol synthesis.
