Association between coronary artery disease and polymorphisms in the attractin-like 1 protein and kinesin-like protein 6 genes
International Journal of Development Research
Association between coronary artery disease and polymorphisms in the attractin-like 1 protein and kinesin-like protein 6 genes
Received 19th September, 2019; Received in revised form 06th October, 2019; Accepted 10th November, 2019; Published online 31th December, 2019
Copyright © 2019, Dinaldo C Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: It is postulated that, in animal models, the Attractin-like 1 protein (ATRNL1) gene is correlated to energy balance and homeostasis, however, there is no information on the influence of ATRL1 polymorphism (rs180706) in humans. Our objective was to evaluate associations between polymorphisms in the ATRNL1 (rs 180706) and KIF6 (rs 20455) genes and coronary artery disease (CAD). Materials and Methods: A cross-sectional and analytical study was carried out from November 2018 to June 2019 that enrolled patients with CAD according to coronary angiography. Results: A total of 404 individuals (204 with CAD and 200 healthy controls) were evaluated.In the ATRLN1 polymorphism (rs 180706) the comparison between sick and healthy regarding the AA allele revealed 16 p (7.8%) vs 29 p (14.5%), p = 0.03 and regarding the CC allele 101 p (49.5%) vs 75 p (37.5%). In KIF6 polymorphism (RS 20455) there were no differences between healthy patients and controls. Conclusion: This is the first study to describe the association between ATRNL1 (rs 180706) gene polymorphism and CAD. The prevalence of the AA genotype in this polymorphism was lower in the disease group when compared to the control group.
